N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

Base Information

Chemical Name:N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine
CAS No.:666724-47-6
Molecular Formula:C₃₃H₃₅N₃O₇Se
Molecular Weight:664.617
Hs Code.:

N<sup>4</sup>-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

Synonyms:N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

Chemical Property:

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Technology Process of N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

There total 10 articles about N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 666724-46-5
N⁴-acetyl-3'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methylcytidine

: 666724-47-6
N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1021/ja038481k

Reference yield:

: 393802-82-9
5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-Se-methoxyuridine

: 666724-47-6
N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

2: DMAP; triethylamine / CH₂Cl₂ / 1 h / 20 °C

3: 395 mg / aq. ammonia / tetrahydrofuran / 20 °C

4: 94 percent / pyridine / 0.5 h / 20 °C

5: 87 percent / TBAF; AcOH / tetrahydrofuran / 2.5 h / 20 °C

With pyridine; 1H-imidazole; dmap; ammonium hydroxide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja038481k

Reference yield:

: 3736-77-4
2,2'-Anhydrouridine

: 666724-47-6
N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-methylseleno-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 7 steps

1: 67 percent / pyridine / 20 °C

2: 92 percent / sodium borohydride / tetrahydrofuran; ethanol / 2 h / 20 °C

3: 95 percent / imidazole / dimethylformamide / 18 h / 20 °C

4: DMAP; triethylamine / CH₂Cl₂ / 1 h / 20 °C

5: 395 mg / aq. ammonia / tetrahydrofuran / 20 °C

6: 94 percent / pyridine / 0.5 h / 20 °C

7: 87 percent / TBAF; AcOH / tetrahydrofuran / 2.5 h / 20 °C

With pyridine; 1H-imidazole; dmap; ammonium hydroxide; sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja038481k