2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

Base Information

Chemical Name:2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione
CAS No.:452296-25-2
Molecular Formula:C₁₈H₁₅ClN₄O₂
Molecular Weight:354.796
Hs Code.:

2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-<i>h</i>]isoquinoline-7,9-dione

Synonyms:2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

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Chemical Property of 2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

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Technology Process of 2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

There total 9 articles about 2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1-(8-amino-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(2-chloro-phenyl)-thiourea

: 452296-25-2
2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; Heating;
DOI:10.1021/jm020113o

Reference yield:

: 5488-36-8
4,4-dimethyl-4H-isoquinoline-1,3-dione

: 452296-25-2
2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / H₂SO₄; HNO₃ / 0 - 5 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 2585.81 Torr

3: 86 percent / 3 h / 20 °C

4: 90percent aq. HNO₃ / -20 °C

5: 99 percent / 90percent aq. H₂SO₄ / 8 h / 70 °C

6: 100 percent / H₂ / PtO₂ / methanol / 1.25 h / 2585.81 Torr

7: ethyl acetate / 20 °C

8: 93 percent / DCC / tetrahydrofuran / Heating

With sulfuric acid; hydrogen; nitric acid; dicyclohexyl-carbodiimide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm020113o

Reference yield:

: 14576-21-7
4,4-dimethyl-7-nitro-2H-3,4-dihydro-isoquinolin-1,3-dione

: 452296-25-2
2-(2-chloro-phenylamino)-6,6-dimethyl-1,6-dihydro-imidazo[4,5-h]isoquinoline-7,9-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol / 1.5 h / 2585.81 Torr

2: 86 percent / 3 h / 20 °C

3: 90percent aq. HNO₃ / -20 °C

4: 99 percent / 90percent aq. H₂SO₄ / 8 h / 70 °C

5: 100 percent / H₂ / PtO₂ / methanol / 1.25 h / 2585.81 Torr

6: ethyl acetate / 20 °C

7: 93 percent / DCC / tetrahydrofuran / Heating

With hydrogen; dicyclohexyl-carbodiimide; platinum(IV) oxide; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1021/jm020113o