N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide
CAS No.:181271-44-3
Molecular Formula:C₂₂H₂₄N₂O₄S
Molecular Weight:412.51
Hs Code.:

Synonyms:N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

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Chemical Property of N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

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Technology Process of N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

There total 9 articles about N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 181271-37-4
Acetic acid 3-acetoxy-2-[2-(toluene-4-sulfonyl)-8-(toluene-4-sulfonylamino)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-7-yl]-propyl ester

: 181271-44-3
N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

Guidance literature:: With potassium hydroxide; In methanol; for 16h; Heating;
DOI:10.3987/com-96-7493

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 181271-44-3
N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: 53 percent / POCl₃ / 16 h / y

2: 64 percent / K₂CO₃ / 1,2-dimethoxy-ethane / 20 h / Ambient temperature

3: 72 percent / Pd(OAc)2, tri-o-tolylphosphine, tetrabutylammonium chloride, triethylamine / acetonitrile / 20 h / 110 °C

4: 64 percent / phenyllithium / tetrahydrofuran; diethyl ether; cyclohexane / 1 h / 0 °C

5: 75 percent / HCl / 2 h / Ambient temperature

6: CH₂Cl₂; pyridine / 24 h / Ambient temperature

7: 77 percent / TMSCl, NaI / acetonitrile / 1 h / 0 °C

8: 57 percent / FeCl₃ / CH₂Cl₂ / 0.75 h / 0 °C

9: 70 percent / 3M aq. KOH / methanol / 16 h / Heating

With hydrogenchloride; palladium diacetate; potassium hydroxide; chloro-trimethyl-silane; tetrabutyl-ammonium chloride; iron(III) chloride; potassium carbonate; phenyllithium; triethylamine; tris-(o-tolyl)phosphine; sodium iodide; trichlorophosphate; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; cyclohexane; acetonitrile;
DOI:10.3987/com-96-7493

Reference yield:

: 181271-36-3
Acetic acid (E)-2-acetoxymethyl-4-[3-(2-oxo-ethyl)-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-but-3-enyl ester

: 181271-44-3
N-[7-(2-Hydroxy-1-hydroxymethyl-ethyl)-8,9-dihydro-2H-2-aza-benzo[cd]azulen-8-yl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / FeCl₃ / CH₂Cl₂ / 0.75 h / 0 °C

2: 70 percent / 3M aq. KOH / methanol / 16 h / Heating

With potassium hydroxide; iron(III) chloride; In methanol; dichloromethane;
DOI:10.3987/com-96-7493