rac-4-(2-AMino-3,3-diMethyl-1-oxobutyl)benzonitrile Hydrochloride

Base Information

Chemical Name:rac-4-(2-AMino-3,3-diMethyl-1-oxobutyl)benzonitrile Hydrochloride
CAS No.:1373046-75-3
Molecular Formula:C₁₃H₁₆N₂O*ClH
Molecular Weight:252.744
Hs Code.:
Mol file:1373046-75-3.mol

Synonyms:4-(2-amino-3,3-dimethyl-butyryl)-benzonitrile hydrochloride

Suppliers and Price of rac-4-(2-AMino-3,3-diMethyl-1-oxobutyl)benzonitrile Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rac-4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrileHydrochloride
25mg
$ 160.00

Crysdot
4-(2-Amino-3,3-dimethylbutanoyl)benzonitrilehydrochloride 97%
1g
$ 772.00

Total 2 raw suppliers

Chemical Property of rac-4-(2-AMino-3,3-diMethyl-1-oxobutyl)benzonitrile Hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

rac-4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrileHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-(2-Amino-3,3-dimethyl-1-oxobutyl)benzonitrile hydrochloride is used as a reagent to synthesize phenyloxobutanylpyridinylpiperazinecarboxamide derivatives, compounds that have TRPA1 receptor antagonistic properties.

Technology Process of rac-4-(2-AMino-3,3-diMethyl-1-oxobutyl)benzonitrile Hydrochloride

There total 4 articles about rac-4-(2-AMino-3,3-diMethyl-1-oxobutyl)benzonitrile Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1373046-74-2
tert-butyl 1-(4-cyanophenyl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

: 1373046-75-3
4-(2-amino-3,3-dimethyl-butyryl)-benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; at 0 - 20 ℃; for 8h; Product distribution / selectivity;

Reference yield:

: 169870-82-0
2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid

: 1373046-75-3
4-(2-amino-3,3-dimethyl-butyryl)-benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 25 °C

1.2: 48 h / 41 °C

2.1: TurboGrignard / tetrahydrofuran / 4.23 h / -13 - 0 °C / Inert atmosphere

2.2: -10 - 20 °C

2.3: 0.5 h / 0 - 40 °C

3.1: hydrogenchloride / methanol / 8 h / 0 - 20 °C

With hydrogenchloride; TurboGrignard; 1,1'-carbonyldiimidazole; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1373046-69-5
tert-butyl 1-(methoxy(methyl)amino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate

: 1373046-75-3
4-(2-amino-3,3-dimethyl-butyryl)-benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 4.23 h / -13 - 0 °C / Inert atmosphere

1.2: -10 - 20 °C

1.3: 0.5 h / 0 - 40 °C

2.1: hydrogenchloride / methanol / 8 h / 0 - 20 °C

With hydrogenchloride; TurboGrignard; In tetrahydrofuran; methanol;