(1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

Base Information

Chemical Name:(1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol
CAS No.:312326-80-0
Molecular Formula:C₂₂H₂₈O₃S
Molecular Weight:372.529
Hs Code.:

Synonyms:(1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

Chemical Property:

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Technology Process of (1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

There total 7 articles about (1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 531557-71-8
(1R,2R)-1,2-dihydroxy-4-[1-(phenylsulfanyl)cyclohexyl]butan-4-one

: 312326-80-0
(1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; at -25 ℃; for 168000h;
DOI:10.1039/b208558e

Reference yield:

: 311806-86-7
(1RS)-1-[1-(phenylsulfanyl)cyclohexyl]but-3-en-1-ol

: 312326-80-0
(1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / PPh₃; Et₃N / Pd(OAc)2 / acetonitrile / 6 h / Heating

2: 72 percent / pyridinium dichromate / CH₂Cl₂ / 72 h / 20 °C

3: 92 percent / AD-mix-β; methanesulfonamide; H2O / 2-methyl-propan-2-ol / 20 °C

4: 75 percent / tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 168000 h / -25 °C

With dipyridinium dichromate; methanesulfonamide; AD-mix-β; water; triethylamine; triphenylphosphine; tetramethylammonium triacetoxyborohydride; palladium diacetate; In dichloromethane; acetic acid; acetonitrile; tert-butyl alcohol; 1: Heck reaction / 3: Sharpless assymetric dihydroxylation;
DOI:10.1039/b208558e

Reference yield:

: 591-50-4
iodobenzene

: 312326-80-0
(1R,2R,4R)-4-[1-(phenylsulfanyl)cyclohexyl]-1-phenylbutane-1,2,4-triol

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / NEt₃ / Pd(OAc)2; Ph₃P / acetonitrile / 24 h / 80 °C

2: 72 percent / PDC / CH₂Cl₂ / 20 °C

3: 92 percent / aq. MeSO2NH2; AD-mix-β / 2-methyl-propan-2-ol / 20 °C

4: 75 percent / Me₄N⁽¹⁺⁾*BH(OAc)3^(1-); AcOH / acetonitrile / 168 h / -20 °C

With dipyridinium dichromate; methanesulfonamide; AD-mix-β; acetic acid; triethylamine; tetramethylammonium triacetoxyborohydride; palladium diacetate; triphenylphosphine; In dichloromethane; acetonitrile; tert-butyl alcohol; 1: Phenylation / 2: Oxidation / 3: Sharpless asymmetric dihydroxylation / 4: Reduction;
DOI:10.1039/b005336h