2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester
• CAS No.: 117949-75-4
• Molecular Formula: C₁₉H₂₀F₃N₂O₆P
• Molecular Weight: 460.347

Synonyms:2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

Chemical Property of 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

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Technology Process of 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester

There total 4 articles about 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-formyl-6-methyl-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3-carboxylate (115550-27-1) → 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester (117949-75-4)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol; water; for 2h; Yield given; Ambient temperature;

DOI:10.1248/cpb.35.4819

Reference yield:

4,4-dimethoxy-3-oxo-butyric acid methyl ester (60705-25-1) → 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester (117949-75-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / NH₃ / methanol / 20 h

2: 45 percent / acetonitrile / 36 h / Heating

3: 82 percent / 6 N HCl / acetone / 96 h / 0 - 10 °C

4: hydroxylamine hydrochloride, NaOAc / methanol; H₂O / 2 h / Ambient temperature

With hydrogenchloride; hydroxylamine hydrochloride; ammonia; sodium acetate; In methanol; water; acetone; acetonitrile;

DOI:10.1248/cpb.35.4819

Reference yield:

methyl 3-amino-4,4-dimethoxy-2-butanoate (85396-57-2) → 2-(Hydroxyimino-methyl)-6-methyl-5-(2-oxo-2λ5-[1,3,2]dioxaphosphinan-2-yl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid methyl ester (117949-75-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / acetonitrile / 36 h / Heating

2: 82 percent / 6 N HCl / acetone / 96 h / 0 - 10 °C

3: hydroxylamine hydrochloride, NaOAc / methanol; H₂O / 2 h / Ambient temperature

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; In methanol; water; acetone; acetonitrile;

DOI:10.1248/cpb.35.4819

upstream raw materials:

methyl 2-formyl-6-methyl-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3-carboxylate

4,4-dimethoxy-3-oxo-butyric acid methyl ester

methyl 3-amino-4,4-dimethoxy-2-butanoate

methyl 2-dimethoxymethyl-6-methyl-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3-carboxylate

Downstream raw materials:

methyl 2-cyano-6-methyl-5-(2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3-carboxylate

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