Technology Process of 3H-Imidazo[4,5-g]quinazoline-4,8,9(5H)-trione, 2,6-bis(bromomethyl)-3-methyl- (9CI)
There total 8 articles about 3H-Imidazo[4,5-g]quinazoline-4,8,9(5H)-trione, 2,6-bis(bromomethyl)-3-methyl- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 73 percent / pyridine / benzene / 15 h / Ambient temperature
2: 64 percent / conc. H2SO4/90percent HNO3 / 1 h / Ambient temperature
3: 66 percent / H2 / 5percent Pd/C / methanol / 3.5 h / 2327.2 Torr
4: 83 percent / pyridine / benzene / 3 h / Ambient temperature
5: 81 percent / 90percent HNO3, H2SO4 / 1 h / Ambient temperature
6: 81 percent / NH3 (liquid) / methanol / 8 h / Ambient temperature
7: 77 percent / H2 / Pd/C / methanol / 2 h / 2327.2 Torr
8: 1.) 48percent aq. HBr, 2.) potassium nitrosodisulfonate, KH2PO4 / 1.) 120 deg C, 6 h, 2.) H2O, 1.5 h
With
pyridine; potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; sulfuric acid; ammonia; hydrogen bromide; hydrogen; nitric acid;
palladium on activated charcoal;
In
methanol; benzene;
DOI:10.1021/jo00276a022
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / pyridine / benzene / 3 h / Ambient temperature
2: 81 percent / 90percent HNO3, H2SO4 / 1 h / Ambient temperature
3: 81 percent / NH3 (liquid) / methanol / 8 h / Ambient temperature
4: 77 percent / H2 / Pd/C / methanol / 2 h / 2327.2 Torr
5: 1.) 48percent aq. HBr, 2.) potassium nitrosodisulfonate, KH2PO4 / 1.) 120 deg C, 6 h, 2.) H2O, 1.5 h
With
pyridine; potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; sulfuric acid; ammonia; hydrogen bromide; hydrogen; nitric acid;
palladium on activated charcoal;
In
methanol; benzene;
DOI:10.1021/jo00276a022
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 66 percent / H2 / 5percent Pd/C / methanol / 3.5 h / 2327.2 Torr
2: 83 percent / pyridine / benzene / 3 h / Ambient temperature
3: 81 percent / 90percent HNO3, H2SO4 / 1 h / Ambient temperature
4: 81 percent / NH3 (liquid) / methanol / 8 h / Ambient temperature
5: 77 percent / H2 / Pd/C / methanol / 2 h / 2327.2 Torr
6: 1.) 48percent aq. HBr, 2.) potassium nitrosodisulfonate, KH2PO4 / 1.) 120 deg C, 6 h, 2.) H2O, 1.5 h
With
pyridine; potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; sulfuric acid; ammonia; hydrogen bromide; hydrogen; nitric acid;
palladium on activated charcoal;
In
methanol; benzene;
DOI:10.1021/jo00276a022
