C₂₄H₂₁FN₄O₃

Base Information

Chemical Name:C₂₄H₂₁FN₄O₃
CAS No.:1438246-39-9
Molecular Formula:C₂₄H₂₁FN₄O₃
Molecular Weight:432.454
Hs Code.:

C<sub>24</sub>H<sub>21</sub>FN<sub>4</sub>O<sub>3</sub>

Synonyms:C₂₄H₂₁FN₄O₃

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Chemical Property of C₂₄H₂₁FN₄O₃

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Technology Process of C₂₄H₂₁FN₄O₃

There total 4 articles about C₂₄H₂₁FN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1442646-30-1
ethyl cis-4-{[5-(5-fluoro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylate

: 1438246-39-9
C₂₄H₂₁FN₄O₃

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 40 ℃;
DOI:10.1021/ml400168h

Reference yield:

: 13466-38-1
5-bromopyridin-2-ol

: 1438246-39-9
C₂₄H₂₁FN₄O₃

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 40 h / 20 - 55 °C / Inert atmosphere

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

4: lithium hydroxide / tetrahydrofuran; water / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; potassium acetate; sodium carbonate; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Mitsunobu Displacement / 3: |Suzuki Coupling;
DOI:10.1021/ml400168h

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1438246-39-9
C₂₄H₂₁FN₄O₃

Guidance literature:: Multi-step reaction with 3 steps

1: potassium peroxymonosulfate / N,N-dimethyl-formamide; water / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water / 40 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium peroxymonosulfate; sodium carbonate; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1021/ml400168h