2H-Benzimidazole-2-thione,4-fluoro-1,3-dihydro-(9CI)

Base Information

• Chemical Name: 2H-Benzimidazole-2-thione,4-fluoro-1,3-dihydro-(9CI)
• CAS No.: 121712-03-6
• Molecular Formula: C₇H₅FN₂S
• Molecular Weight: 168.195
• Mol file: 121712-03-6.mol

Synonyms:2H-Benzimidazole-2-thione,4-fluoro-1,3-dihydro-(9CI);4-FLUORO-1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-THIONE

Chemical Property of 2H-Benzimidazole-2-thione,4-fluoro-1,3-dihydro-(9CI)

Chemical Property:

• PSA: 67.48000
• LogP: 1.99070

Purity/Quality:

99%min ^*data from raw suppliers

4-FLUORO-1,3-DIHYDRO-2H-BENZIMIDAZOLE-2-THIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Benzimidazole-2-thione,4-fluoro-1,3-dihydro-(9CI)

There total 4 articles about 2H-Benzimidazole-2-thione,4-fluoro-1,3-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Fluoroaniline (348-54-9) → 4-fluorobenzimidazolyl-2-thione (121712-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 0.5 h / Heating

2: 1.) conc. HNO₃; 2.) HCl / 1.) acetic anhydride-acetic acid, 0-5 deg C

3: hydrazine hydrate / Raney nickel

4: KOH

With hydrogenchloride; potassium hydroxide; nitric acid; hydrazine hydrate; nickel; In acetic acid;

DOI:10.1016/S0022-1139(00)82753-0

Reference yield:

N-(2-fluorophenyl)acetamide (399-31-5) → 4-fluorobenzimidazolyl-2-thione (121712-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) conc. HNO₃; 2.) HCl / 1.) acetic anhydride-acetic acid, 0-5 deg C

2: hydrazine hydrate / Raney nickel

3: KOH

With hydrogenchloride; potassium hydroxide; nitric acid; hydrazine hydrate; nickel;

DOI:10.1016/S0022-1139(00)82753-0

Reference yield:

2-fluoro-6-nitroaniline (17809-36-8) → 4-fluorobenzimidazolyl-2-thione (121712-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / Raney nickel

2: KOH

With potassium hydroxide; hydrazine hydrate; nickel;

DOI:10.1016/S0022-1139(00)82753-0

upstream raw materials:

carbon disulfide

3-fluorobenzene-1,2-diamine

2-Fluoroaniline

N-(2-fluorophenyl)acetamide

Downstream raw materials:

2,3-dihydro-8-fluorothiazolo<3,2a>benzimidazole

Refernces