triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

Base Information

Chemical Name:triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide
CAS No.:1207460-25-0
Molecular Formula:Br*C₃₂H₂₈ClFN₂P
Molecular Weight:605.917
Hs Code.:

Synonyms:triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

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Chemical Property of triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

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Technology Process of triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

There total 7 articles about triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1207460-23-8
(2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidin-5-yl)methanol

: 603-35-0
triphenylphosphine

: 1207460-25-0
triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

Guidance literature:: (2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidin-5-yl)methanol; With phosphorus tribromide; In dichloromethane; at 0 - 5 ℃; for 3h;

triphenylphosphine; In toluene; at 110 - 115 ℃; for 4h;
DOI:10.2174/1570178617999201012181526

Reference yield:

: 1207460-24-9
5-(bromomethyl)-2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidine

: 603-35-0
triphenylphosphine

: 1207460-25-0
triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

Guidance literature:: In toluene; at 110 ℃;

Reference yield:

: 4-(4-fluorophenyl)-6-isopropyl-5-methoxycarbonyl-3,4-dihydropyrimidine-2(1H)-one

: 1207460-25-0
triphenyl[2-chloro-{4-(4-fluorophenyl)-6-isopropylpyrimidin-5-ylmethyl}phosphonium]bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 2 h / 100 °C

2.1: diisobutylaluminium hydride / toluene / 3 h / 0 °C

3.1: phosphorus tribromide / dichloromethane / 3 h / 0 - 5 °C

3.2: 4 h / 110 - 115 °C

With phosphorus tribromide; diisobutylaluminium hydride; trichlorophosphate; In dichloromethane; toluene;
DOI:10.2174/1570178617999201012181526