4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

Base Information

Chemical Name:4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride
CAS No.:1297538-12-5
Molecular Formula:C₁₂H₁₁N₅O₂*ClH
Molecular Weight:293.713
Hs Code.:

Synonyms:4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

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Chemical Property of 4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

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Technology Process of 4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

There total 4 articles about 4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297538-10-3
tert-butyl 2-(3-(4-cyano-3-nitrophenyl)-1H-pyrazol-1-yl)ethylcarbamate

: 1297538-12-5
4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; dichloromethane; at 20 ℃;

Reference yield:

: 34662-32-3
4-chloro-2-nitrobenzonitrile

: 1297538-12-5
4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4.5 h / 90 °C

2.1: hydrogenchloride / ethanol / 1.5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 0.5 h / 160 °C / Microwave irradiation

4.1: hydrogenchloride / dichloromethane; ethanol / 20 °C

With hydrogenchloride; sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1297538-05-6
2-nitro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile

: 1297538-12-5
4-(1-(2-aminoethyl)-1H-pyrazol-3-yl)-2-nitrobenzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 1.5 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0.5 h / 160 °C / Microwave irradiation

3.1: hydrogenchloride / dichloromethane; ethanol / 20 °C

With hydrogenchloride; sodium hydride; In ethanol; dichloromethane; N,N-dimethyl-formamide;