2-TrifluoroMethyl-2'-Methoxychalcone

Base Information

• Chemical Name: 2-TrifluoroMethyl-2'-Methoxychalcone
• CAS No.: 1309371-03-6
• Molecular Formula: C₁₇H₁₃F₃O₂
• Molecular Weight: 306.284
• Mol file: 1309371-03-6.mol

Synonyms:(E)-1-(2-methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one

Chemical Property of 2-TrifluoroMethyl-2'-Methoxychalcone

Chemical Property:

• Boiling Point: 395.6±42.0 °C(Predicted)
• Density: 1.238±0.06 g/cm3(Predicted)
• Solubility.: ≤11mg/ml in ethanol;5mg/ml in DMSO;14mg/ml in dimethyl formamide

Purity/Quality:

99% ^*data from raw suppliers

2-Trifluoromethyl-2''-methoxychalcone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Trifluoromethyl-2'-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Nrf2 activation is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. 2-Trifluoromethyl-2'-methoxychalcone is a potent activator of Nrf2, both in vitro and in mice. Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2'-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1. Furthermore, treatment of mice mice with 50 mg/kg 2-trifluoromethyl-2’-methoxychalcone leads to a 4.5- and 4.6-fold increase in the expression of GCLM and NQO1, respectively, in the small intestine compared to controls.[Cayman Chemical] 2-Trifluoromethyl-2''-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2''-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2''-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.

Technology Process of 2-TrifluoroMethyl-2'-Methoxychalcone

There total 2 articles about 2-TrifluoroMethyl-2'-Methoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

→ (E)-1-(2-methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one (1309371-03-6)

Guidance literature:

Reference yield: 40.0%

2-Methoxyacetophenone (579-74-8) + 2-Trifluoromethylbenzaldehyde (447-61-0) → (E)-1-(2-methoxyphenyl)-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-one (1309371-03-6)

Guidance literature:

With lithium hydroxide monohydrate; In ethanol; at 20 ℃; for 2.25h;

DOI:10.1016/j.bmc.2015.08.012

upstream raw materials:

2-Methoxyacetophenone

2-Trifluoromethylbenzaldehyde

Refernces

• 1、 -. "CHALCONE DERIVATIVES AS NRF2 ACTIVATORS". Page/Page column 51. . Retrieved 2012/09/11.