4-Hydroxy-1,2-benzisothiazol

Base Information

• Chemical Name: 4-Hydroxy-1,2-benzisothiazol
• CAS No.: 67982-15-4
• Molecular Formula: C₇H₅NOS
• Molecular Weight: 151.189
• Mol file: 67982-15-4.mol

Synonyms:4-Hydroxy-1,2-benzisothiazol

Chemical Property of 4-Hydroxy-1,2-benzisothiazol

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Hydroxy-1,2-benzisothiazol

There total 6 articles about 4-Hydroxy-1,2-benzisothiazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-methoxy-1,2-benzisothiazole (35272-30-1) → 4-Hydroxy-1,2-benzisothiazol (67982-15-4)

Guidance literature:

4-methoxy-1,2-benzisothiazole; With pyridine hydrochloride; at 195 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1021/jm300185p

Reference yield:

4-benzyloxy-benzo[d]isothiazole (67982-16-5) → 4-Hydroxy-1,2-benzisothiazol (67982-15-4)

Guidance literature:

In sulfuric acid;

Reference yield:

2-fluoro-6-methoxybenzaldehyde (146137-74-8) → 4-Hydroxy-1,2-benzisothiazol (67982-15-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium pivalate / tetrahydrofuran / 0.5 h / 0 °C

1.2: 1 h / 20 °C

2.1: methyl-phenyl-thioether / water; acetonitrile / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: pyridine hydrochloride / 2 h / 195 °C

3.2: 2 h / 20 °C

With methyl-phenyl-thioether; pyridine hydrochloride; sodium pivalate; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/jm300185p

upstream raw materials:

4-methoxy-1,2-benzisothiazole

7-Amino-4-methoxy-1,2-benzisothiazol

4-benzyloxy-benzo[d]isothiazole

2-(benzylsulfanyl)-6-methoxybenzaldehyde

Downstream raw materials:

4-(2-chloro-4-nitrophenoxy)-1,2-benzisothiazole

4-(1,2-benzisothiazol-4-yloxy)-3-chloroaniline

C₁₃H₇BrN₂O₃S

C₁₄H₁₀N₂O₄S