{tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

Base Information

Chemical Name:{tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester
CAS No.:867326-90-7
Molecular Formula:C₂₀H₃₁NO₅Si
Molecular Weight:393.555
Hs Code.:

{<i>tert</i>-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

Synonyms:{tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

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Chemical Property of {tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

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Technology Process of {tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

There total 9 articles about {tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 867326-80-5
{tert-butoxycarbonyl-[(1R)-1-(tert-butyldiphenylsilanyloxymethyl)-2-(dimethylphenylsilanyl)-allyl]-amino}-acetic acid methyl ester

: (5R)-5-[1-(dimethylphenylsilanyl)-vinyl]-2-oxo-morpholine-4-carboxylic acid methyl ester

: 867326-90-7
{tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

Guidance literature:: With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 18.25h;
DOI:10.1039/b510756c

Reference yield:

: {tert-butoxycarbonyl-[1-(tert-butyldiphenylsilanyloxymethyl)-2-(dimethylphenylsilanyl)-allyl]-amino}-acetic acid methyl ester

: (5S)-5-[1-(dimethylphenylsilanyl)-vinyl]-2-oxo-morpholine-4-carboxylic acid tert-butyl ester

: (5R)-5-[1-(dimethylphenylsilanyl)-vinyl]-2-oxo-morpholine-4-carboxylic acid methyl ester

: {tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

: 867326-90-7
{tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

Guidance literature:: With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 0 - 20 ℃; for 18.25h; Title compound not separated from byproducts;
DOI:10.1039/b510756c

Reference yield:

: 867326-72-5
[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-carbamic acid tert-butyl ester

: 867326-90-7
{tert-butoxycarbonyl-[2-(dimethyl-phenyl-silanyl)-1-hydroxymethyl-allyl]-amino}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / imidazole / dimethylformamide / 16 h / 20 °C

2: 93 percent / TFA / CH₂Cl₂ / 0.5 h / 0 °C

3: 80 percent / Et₃N / dimethylformamide / 1.25 h / 0 °C

4: 94 percent / Et₃N / 40 h / Heating

5: 65 percent / pyridine; HF*pyridine / tetrahydrofuran / 18.25 h / 0 - 20 °C

With pyridine; 1H-imidazole; pyridine hydrogenfluoride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b510756c