(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Base Information

Chemical Name:(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid
CAS No.:1215118-15-2
Molecular Formula:C₂₇H₂₈F₃NO₃
Molecular Weight:471.519
Hs Code.:

Synonyms:(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Chemical Property of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

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Technology Process of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

There total 16 articles about (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215119-03-1
Methyl 2-(7-(4-Cyclopentyl-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1215118-15-2
(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Methyl 2-(7-(4-Cyclopentyl-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate; With water; lithium hydroxide; In 1,4-dioxane; at 25 - 60 ℃; for 1h;

With citric acid; In tert-butyl methyl ether;

Reference yield:

: 1215118-78-7
tert-Butyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1215118-15-2
(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: With rac-cysteine; trifluoroacetic acid; at 23 ℃; for 0.25h; Sealed vial;

Reference yield:

: 37033-95-7
5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester

: 1215118-15-2
(R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl) benzyloxy)-9-methyl-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / toluene; mineral oil / 0.83 h

1.2: 20 - 70 °C

1.3: 24 h / Reflux

2.1: tetrahydrofuran / 24 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran / 24 h / 11636.1 Torr

4.1: hydrogen; acetic acid / 20 % Pd(OH)2/C / ethanol; tetrahydrofuran / 50 °C / 10343.2 - 25858.1 Torr

5.1: palladium on carbon / toluene / 48 h / 80 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C / Sealed vial

7.1: N-iodo-succinimide / dichloromethane / 0.5 h / 0 °C / Sealed vessel

8.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere; Sealed tube

9.1: trifluoroacetic acid; rac-cysteine / 0.25 h / 23 °C / Sealed vial

With N-iodo-succinimide; rac-cysteine; hydrogen; sodium hydride; caesium carbonate; acetic acid; trifluoroacetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 20 % Pd(OH)2/C; palladium on carbon; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;