2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester
• CAS No.: 175402-07-0
• Molecular Formula: C₁₆H₁₀N₂O₃
• Molecular Weight: 278.267
• Mol file: 175402-07-0.mol

Synonyms:2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester

Chemical Property of 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester

There total 2 articles about 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-cyanobenzoyl chlorIde (6068-72-0) + methyl 3-amino-4-hydroxybenzoate (536-25-4) → 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester (175402-07-0)

Guidance literature:

In 1,4-dioxane; acetonitrile; at 180 ℃; for 8h; Microwave irradiation;

Reference yield:

4-cyanobenzoic Acid (619-65-8,333406-09-0) + methyl 3-amino-4-hydroxybenzoate (536-25-4) → 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester (175402-07-0)

Guidance literature:

With boric acid; In xylene; Yield given; Heating;

DOI:10.1016/0960-894X(95)00590-P

Reference yield: 72.0%

2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid methyl ester (175402-07-0) → 2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid (175402-05-8)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃;

upstream raw materials:

4-cyanobenzoic Acid

methyl 3-amino-4-hydroxybenzoate

4-cyanobenzoyl chlorIde

Downstream raw materials:

2-(4-Cyano-phenyl)-benzooxazole-5-carboxylic acid

(S)-2-Butoxycarbonylamino-3-{[2-(4-cyano-phenyl)-benzooxazole-5-carbonyl]-amino}-propionic acid methyl ester

(S)-2-Butoxycarbonylamino-3-{[2-(4-carbamimidoyl-phenyl)-benzooxazole-5-carbonyl]-amino}-propionic acid methyl ester

(S)-3-{[2-(4-Cyano-phenyl)-benzooxazole-5-carbonyl]-amino}-2-(toluene-4-sulfonylamino)-propionic acid methyl ester