2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

Base Information

Chemical Name:2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile
CAS No.:1359760-19-2
Molecular Formula:C₂₂H₁₅BrFN₃O
Molecular Weight:436.283
Hs Code.:

Synonyms:2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

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Chemical Property of 2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

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Technology Process of 2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

There total 4 articles about 2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359761-10-6
2-(3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)benzonitrile

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1359760-19-2
2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 200 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 871700-37-7
N-(2-fluoro-4-iodophenyl)-N'-methylurea

: 1359760-19-2
2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 200 °C / Microwave irradiation

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 0.25 h / 140 °C / Microwave irradiation

3: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 200 °C / Microwave irradiation

With sodium hydride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide;

Reference yield:

: 139072-17-6
4-iodo-2-fluorophenyl isocyanate

: 1359760-19-2
2-[1-(4-bromo-2-fluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; hexanes / 0.5 h / 23 °C

2: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 200 °C / Microwave irradiation

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 0.25 h / 140 °C / Microwave irradiation

4: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 200 °C / Microwave irradiation

With sodium hydride; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; hexanes; N,N-dimethyl-formamide;