7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide

Base Information

• Chemical Name: 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide
• CAS No.: 186551-61-1
• Molecular Formula: C₂₉H₂₆N₄O₄S
• Molecular Weight: 526.616

Synonyms:7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide

Chemical Property of 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide

There total 6 articles about 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide (186550-31-2) → 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide (186551-61-1)

Guidance literature:

With potassium carbonate; In acetone; for 48h;

DOI:10.1021/jm990040h

Reference yield:

7-hydroxynaphthalene-2-sulfonic acid sodium salt (135-55-7) → 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide (186551-61-1)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / ethanol / 16 h / 20 °C

2: 3.80 g / POCl₃; PCl₅ / 4 h / 120 °C

3: Et₃N / CH₂Cl₂ / 2 h

4: K₂CO₃ / acetone / 48 h

With sodium hydroxide; phosphorus pentachloride; potassium carbonate; triethylamine; trichlorophosphate; In ethanol; dichloromethane; acetone; 1: Methylation / 2: Chlorination / 3: Condensation / 4: Alkylation;

DOI:10.1021/jm990040h

Reference yield:

7-Methoxy-2-naphthalenesulfonyl chloride (56875-60-6) → 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide (186551-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: K₂CO₃ / acetone / 48 h

With potassium carbonate; triethylamine; In dichloromethane; acetone; 1: Condensation / 2: Alkylation;

DOI:10.1021/jm990040h

upstream raw materials:

7-methoxynaphthalene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl]amide

7-hydroxynaphthalene-2-sulfonic acid sodium salt

7-Methoxy-2-naphthalenesulfonyl chloride

[1-(3-cyanobenzyl)-2-oxopyrrolidin-3(S)-yl]carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 186551-61-1 7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-oxo-pyrrolidin-3-yl]-pyridin-2-ylmethyl-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send