tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate
CAS No.:1003315-95-4
Molecular Formula:C₂₃H₂₅N₃O₃S
Molecular Weight:423.536
Hs Code.:

Synonyms:tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

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Chemical Property of tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Chemical Property:

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Technology Process of tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

There total 12 articles about tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095165-53-9
1,1-dimethylethyl [2-[({4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}carbonyl)amino]-4-(2-thienyl)phenyl]carbamate

: 1003315-95-4
tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Guidance literature:: With hydrazine; In ethanol; for 5h; Heating / reflux;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1003315-95-4
tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 2 h / 20 °C

2: triphenylphosphine; palladium diacetate; sodium carbonate / dimethyl sulfoxide; water / 5 h / 100 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol

4: triethylamine; pyridine / dichloromethane / 0 - 20 °C

5: water; potassium carbonate / methanol / 20 °C

With pyridine; dmap; palladium on activated charcoal; water; hydrogen; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; dichloromethane; water; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.03.069

Reference yield:

: 875-51-4
4-Bromo-2-nitroaniline

: 1003315-95-4
tert-butyl (2-(4-(aminomethyl)benzamido)-4-(thiophen-2-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 2 h / 20 °C

2: triphenylphosphine; palladium diacetate; sodium carbonate / dimethyl sulfoxide; water / 5 h / 100 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol

4: triethylamine; pyridine / dichloromethane / 0 - 20 °C

5: water; potassium carbonate / methanol / 20 °C

With pyridine; dmap; palladium on activated charcoal; water; hydrogen; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; dichloromethane; water; dimethyl sulfoxide; 2: |Suzuki Coupling;
DOI:10.1016/j.ejmech.2017.03.069