(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Base Information

Chemical Name:(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone
CAS No.:877438-78-3
Molecular Formula:C₃₀H₄₄O₅Si₂
Molecular Weight:540.847
Hs Code.:

Synonyms:(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Suppliers and Price of (8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

There total 6 articles about (8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 877438-70-5
(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-(propane-1,3-diyldithio)lignano-9,9'-lactone

: 877438-78-3
(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Guidance literature:: With water; bis-[(trifluoroacetoxy)iodo]benzene; In acetonitrile; at 20 ℃; for 0.5h;
DOI:10.1039/b513303c

Reference yield:

: 877438-60-3
(3R)-3-[(propane-1,3-diyldithio)-(4-tert-butyldimethylsilanyloxyphenyl)methyl]butano-4-lactone

: 877438-78-3
(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Guidance literature:: Multi-step reaction with 2 steps

1.1: LHMDS / tetrahydrofuran / 2 h / -78 °C

1.2: 71 percent / N,N-dimethyl-2-imidazolidinone / tetrahydrofuran / -78 - 20 °C

2.1: 70 percent / (CF₃CO₂)2IPh; H₂O / acetonitrile / 0.5 h / 20 °C

With water; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1039/b513303c

Reference yield:

: 877438-46-5
2-(3-tert-butyldimethylsilanyloxyphenyl)-1,3-dithiane

: 877438-78-3
(8R,8'R)-3,3'-bis(tert-butyldimethylsilanyloxy)-7'-oxolignano-9,9'-lactone

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 75 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 2 h / -78 °C

2.1: 64 percent / NaBH₄; KOH / ethanol / 3 h / 0 - 20 °C

3.1: LHMDS / tetrahydrofuran / 2 h / -78 °C

3.2: 71 percent / N,N-dimethyl-2-imidazolidinone / tetrahydrofuran / -78 - 20 °C

4.1: 70 percent / (CF₃CO₂)2IPh; H₂O / acetonitrile / 0.5 h / 20 °C

With potassium hydroxide; sodium tetrahydroborate; n-butyllithium; water; bis-[(trifluoroacetoxy)iodo]benzene; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; acetonitrile; 1.2: Michael addition;
DOI:10.1039/b513303c