methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Name:methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
CAS No.:1352212-18-0
Molecular Formula:C₄₂H₅₀N₁₀O₆
Molecular Weight:790.922
Hs Code.:

methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Synonyms:methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Property of methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Technology Process of methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

There total 13 articles about methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(2S)-pyrrolidin-2-yl]-5-[4-(2-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}pyrimidin-5-yl)phenyl]-1H-benzimidazole hydrochloride

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1352212-18-0
methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: N-methoxycarbonyl-L-valine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃; for 0.333333h;

2-[(2S)-pyrrolidin-2-yl]-5-[4-(2-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}pyrimidin-5-yl)phenyl]-1H-benzimidazole hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1352212-18-0
methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonia / water; methanol / 19.17 h / 20 °C / Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 16 h / 20 °C

3.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 2 h / 20 °C

4.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 16 h / 20 °C

5.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 5 h / 60 °C

6.1: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 120 °C

7.1: hydrogenchloride / indastrial methylated spirit / 3 h / 70 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

8.2: 18 h / 20 °C

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; TurboGrignard; ammonia; sodium hydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; indastrial methylated spirit; water; acetonitrile; mineral oil;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1352212-18-0
methyl {(2S)-1-[(2S)-2-{4-[5-(4-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-benzimidazol-5-yl}phenyl)pyrimidin-2-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water / 0 - 90 °C

2.1: ammonia / water; methanol / 19.17 h / 20 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

3.2: 16 h / 20 °C

4.1: N-Bromosuccinimide / dichloromethane; acetonitrile / 2 h / 20 °C

5.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

5.2: 16 h / 20 °C

6.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 5 h / 60 °C

7.1: potassium phosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 120 °C

8.1: hydrogenchloride / indastrial methylated spirit / 3 h / 70 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

9.2: 18 h / 20 °C

With hydrogenchloride; sodium hypochlorite; potassium phosphate; N-Bromosuccinimide; TurboGrignard; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonia; sodium hydride; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; indastrial methylated spirit; water; acetonitrile; mineral oil;