Technology Process of (+)-(1R,2R,4S,6S)-6-methylcyclohexane-1,2,4-triol
There total 2 articles about (+)-(1R,2R,4S,6S)-6-methylcyclohexane-1,2,4-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tris[(3-methylbutanoyl)oxy]borohydride; acetic acid;
In
acetonitrile;
at -35 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/anie.201409792
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ozone / methanol; dichloromethane / 0.5 h / -78 °C
1.2: 2 h / -78 °C
2.1: acetic acid; sodium tris[(3-methylbutanoyl)oxy]borohydride / acetonitrile / 1 h / -35 °C / Inert atmosphere
With
sodium tris[(3-methylbutanoyl)oxy]borohydride; ozone; acetic acid;
In
methanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201409792
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate / methanol / 25 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / -20 - 20 °C / Inert atmosphere
2.2: 2 h / -50 - 25 °C / Inert atmosphere
3.1: trimethylsilyl bromide; water / methanol; dichloromethane / 0 - 25 °C / Inert atmosphere
With
trimethylsilyl bromide; boron trifluoride diethyl etherate; water; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/anie.201409792
