6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Base Information

Chemical Name:6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)
CAS No.:1616693-41-4
Molecular Formula:C₂₄H₂₈Br₂O₆
Molecular Weight:572.291
Hs Code.:

Synonyms:6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Suppliers and Price of 6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

There total 8 articles about 6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1643613-68-6
6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl alcohol)

: 1616693-41-4
6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Guidance literature:: With phosphorus tribromide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/np500458a

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1616693-41-4
6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; bromine / dichloromethane / 0.5 h / 20 °C

2.1: toluene-4-sulfonic acid / toluene / 24 h / Dean-Stark; Reflux

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: silver trifluoroacetate; iodine / chloroform / 0.5 h

5.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 10 h / 60 °C / Inert atmosphere

6.1: sodium tetrahydroborate / methanol / 8 h / 20 °C

7.1: phosphorus tribromide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; bromine; iodine; silver trifluoroacetate; phosphorus tribromide; toluene-4-sulfonic acid; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; toluene; 5.1: |Sonogashira Cross-Coupling;
DOI:10.1021/np500458a

Reference yield:

: 130611-32-4
2-(2-bromo-3,4,5-trimethoxyphenyl)-1,3-dioxane

: 1616693-41-4
6,6'-(ethyne-1,2-diyl)bis(3,4,5-trimethoxy-2-methylbenzyl bromide)

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: silver trifluoroacetate; iodine / chloroform / 0.5 h

3.1: triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 10 h / 60 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 8 h / 20 °C

5.1: phosphorus tribromide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; iodine; silver trifluoroacetate; phosphorus tribromide; triethylamine; In tetrahydrofuran; methanol; chloroform; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1021/np500458a