3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile

Base Information

• Chemical Name: 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile
• CAS No.: 678171-04-5
• Molecular Formula: C₁₉H₁₄ClN₃O₂
• Molecular Weight: 351.792

Synonyms:3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile

Chemical Property of 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile

Chemical Property:

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Technology Process of 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile

There total 1 articles about 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acetonitrile (75-05-8,26809-02-9) + ethyl 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-3-carboxylate (5606-57-5) → 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile (678171-04-5)

Guidance literature:

With sodium hydride; In benzene; for 8h; Heating;

DOI:10.1016/S0928-0987(03)00162-3

Reference yield: 86.0%

3-phenylpyrazole-5-diazonium + 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile (678171-04-5) → 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxo-2-[3-phenyl-1H-pyrazol-5-ylhydrazono]-propanenitrile (678171-10-3)

Guidance literature:

In ethanol; at 0 - 5 ℃; for 30.5h;

DOI:10.1016/S0928-0987(03)00162-3

Reference yield: 82.0%

3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile (678171-04-5) → 2-bromo-3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile (678171-08-9)

Guidance literature:

With bromine; In acetic acid; for 0.166667h;

DOI:10.1016/S0928-0987(03)00162-3

upstream raw materials:

acetonitrile

ethyl 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-3-carboxylate

Downstream raw materials:

3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-oxo-2-(phenyl-hydrazono)-propionitrile

3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-oxo-2-(p-tolyl-hydrazono)-propionitrile

3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile

2-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carbonyl)-3-p-tolyl-acrylonitrile

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