4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

Base Information

Chemical Name:4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride
CAS No.:1334679-23-0
Molecular Formula:C₁₄H₁₂F₆N₂*ClH
Molecular Weight:358.714
Hs Code.:

Synonyms:4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

Chemical Property:

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Technology Process of 4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

There total 2 articles about 4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₀F₆N₂O₂

: 1334679-23-0
4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

Guidance literature:: With hydrogenchloride; water; at 20 ℃; for 1h;

Reference yield:

: 85068-32-2
3,5-bis(trifluoromethyl)phenylacetonitrile

: 1334679-23-0
4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / 20 - 70 °C / Inert atmosphere

2: hydrogenchloride; water / 1 h / 20 °C

With hydrogenchloride; water; sodium hydride;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1334679-23-0
4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride

: 1334679-24-1
4-(3,5-bis-trifluoromethylphenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Guidance literature:: 4-(3,5-bis-trifluoromethylphenyl)-piperidine-4-carbonitrile hydrochloride; With hydrogenchloride; water; for 84h; Reflux;

di-tert-butyl dicarbonate; With sodium hydroxide; at 20 ℃; for 1h;