N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid

Base Information

• Chemical Name: N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid
• CAS No.: 118869-57-1
• Molecular Formula: C₁₈H₁₈N₆O₅
• Molecular Weight: 398.378
• Mol file: 118869-57-1.mol

Synonyms:N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid

Chemical Property of N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid

There total 3 articles about N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate (118869-53-7) → N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid (118869-57-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00123a001

Reference yield: 31.0%

N-(4-aminobenzoyl)-L-glutamic acid (4271-30-1,532-63-8) + 2-Amino-5-chloromethylpyrazine-3-carbonitrile (40127-91-1) → N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid (118869-57-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.333333h;

DOI:10.1021/jm00105a036

Reference yield:

2-Amino-5-chloromethylpyrazine-3-carbonitrile (40127-91-1) → N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid (118869-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: i-Pr₂EtN / dimethylformamide

2: 100 percent / trifluoroacetic acid / CH₂Cl₂

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a001

upstream raw materials:

di-tert-butyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate

N-(4-aminobenzoyl)-L-glutamic acid

2-Amino-5-chloromethylpyrazine-3-carbonitrile

Downstream raw materials:

N-<4-<<(2-amino-3-carbamoylpyrazin-5-yl)methyl>formamido>benzoyl>-L-glutamic acid

N-<4-<<(2-amino-3-carbamoylpyrazin-5-yl)methyl>amino>benzoyl>-L-glutamic acid