2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

Base Information

Chemical Name:2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol
CAS No.:1435050-81-9
Molecular Formula:C₁₇H₁₉F₂NOS
Molecular Weight:323.407
Hs Code.:

Synonyms:2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

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Chemical Property of 2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

Chemical Property:

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Technology Process of 2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

There total 11 articles about 2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434725-57-1
N-[1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-2-tritylsulfanyl-acetamide

: 1435050-81-9
2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

Guidance literature:: N-[1-(2,4-difluoro-3-phenoxy-phenyl)-propyl]-2-tritylsulfanyl-acetamide; With diborane; In tetrahydrofuran; at 60 ℃;

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 261763-46-6
3-methyl-2,6-difluorophenol

: 1435050-81-9
2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

Guidance literature:: Multi-step reaction with 8 steps

1.1: cesium fluoride / acetonitrile / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 - 90 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; dimethyl sulfoxide / 80 °C / Inert atmosphere

4.1: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

5.1: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

6.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

8.1: diborane / tetrahydrofuran / 60 °C

8.2: 1 h / 20 °C

With hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 98-80-6
phenylboronic acid

: 1435050-81-9
2-[(S)-1-(2,4-difluoro-3-phenoxy-phenyl)-propylamino]-ethanethiol

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper diacetate; pyridine; pyridine N-oxide / dichloromethane / 48 h / 20 °C / Molecular sieve

2.1: titanium(IV) tetraethanolate / dichloromethane / Inert atmosphere

3.1: tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

4.1: hydrogenchloride / methanol; 1,4-dioxane / 1 h

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 48 h / 20 °C

6.1: diborane / tetrahydrofuran / 60 °C

6.2: 1 h / 20 °C

With pyridine; pyridine N-oxide; hydrogenchloride; titanium(IV) tetraethanolate; copper diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; diborane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;