4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole

Base Information

• Chemical Name: 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole
• CAS No.: 118617-86-0
• Molecular Formula: C₂₉H₃₁NO₅S
• Molecular Weight: 505.635
• Mol file: 118617-86-0.mol

Synonyms:4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole

Chemical Property of 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole

There total 3 articles about 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(+/-)-1-<(4-methylphenyl)sulfonyl>-α-(2-methyl-1-propenyl)-1H-indole-4-methanol (90150-60-0) + para-methoxybenzyl chloride (88023-78-3) → 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole (118617-86-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 10h; Ambient temperature;

DOI:10.1016/S0040-4039(00)95608-9

Reference yield:

4-methoxybenzyl alcohol sodium salt (53942-86-2) → 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole (118617-86-0)

Guidance literature:

Multi-step reaction with 3 steps

2: sulfuryl chloride / CH₂Cl₂ / -78 °C

3: 100 percent / diisopropylethylamine / CH₂Cl₂ / 10 h / Ambient temperature

With sulfuryl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)95608-9

Reference yield:

1-methoxy-4-{[(methylsulfanyl)methoxy]methyl}-benzene (88023-83-0) → 4-[1-(4-Methoxy-benzyloxymethoxy)-3-methyl-but-2-enyl]-1-(toluene-4-sulfonyl)-1H-indole (118617-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl chloride / CH₂Cl₂ / -78 °C

2: 100 percent / diisopropylethylamine / CH₂Cl₂ / 10 h / Ambient temperature

With sulfuryl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(00)95608-9

upstream raw materials:

(+/-)-1-<(4-methylphenyl)sulfonyl>-α-(2-methyl-1-propenyl)-1H-indole-4-methanol

para-methoxybenzyl chloride

4-methoxybenzyl alcohol sodium salt

1-methoxy-4-{[(methylsulfanyl)methoxy]methyl}-benzene

Downstream raw materials:

(E)-2-Methyl-4-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-but-3-en-2-ol