N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine

Base Information

Chemical Name:N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine
CAS No.:3409-22-1
Molecular Formula:C₂₅H₂₆N₂
Molecular Weight:354.495
Hs Code.:
DSSTox Substance ID:DTXSID801170795
Pharos Ligand ID:A32MT8DV9V8J
ChEMBL ID:CHEMBL171102

Synonyms:CHEMBL171102;DTXSID801170795;BDBM50474497;N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine;3409-22-1

Suppliers and Price of N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:354.209598838
Heavy Atom Count:27
Complexity:503

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)CCC1=C(C2=CC=CC=C2C1)C(C3=CC=CC=C3)C4=CC=CC=N4

Technology Process of N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine

There total 5 articles about N,N-Dimethyl-3-(phenyl-2-pyridinylmethyl)-1H-indene-2-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101-82-6
2-Benzylpyridine

: 3409-21-0
2-[2-(dimethylamino)ethyl]indan-1-one

: 3409-22-1
Dimethyl-{2-[3-(phenyl-pyridin-2-yl-methyl)-1H-inden-2-yl]-ethyl}-amine

Guidance literature:: 2-Benzylpyridine; With n-butyllithium; In diethyl ether; at -78 ℃; for 2h;

2-[2-(dimethylamino)ethyl]indan-1-one; In diethyl ether; at 20 ℃;

With hydrogenchloride; for 1h; Further stages.; Heating;
DOI:10.1021/jm020895l

Reference yield:

: 1805-03-4
2-benzyl-2-[2-(dimethylamino)ethyl]malonic acid diethyl ester

: 3409-22-1
Dimethyl-{2-[3-(phenyl-pyridin-2-yl-methyl)-1H-inden-2-yl]-ethyl}-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / aq. NaOH / ethanol / 4 h / Heating

2.1: 41 percent / polyphosphoric acid / 0.33 h / 140 - 150 °C

3.1: BuLi / diethyl ether / 2 h / -78 °C

3.2: diethyl ether / 20 °C

3.3: aq. HCl / 1 h / Heating

With sodium hydroxide; n-butyllithium; PPA; In diethyl ether; ethanol;
DOI:10.1021/jm020895l

Reference yield:

: 607-81-8
diethyl 2-benzylmalonate

: 3409-22-1
Dimethyl-{2-[3-(phenyl-pyridin-2-yl-methyl)-1H-inden-2-yl]-ethyl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / toluene / 1 h / Heating

1.2: 85 percent / toluene / 6 h / Heating

2.1: 77 percent / aq. NaOH / ethanol / 4 h / Heating

3.1: 41 percent / polyphosphoric acid / 0.33 h / 140 - 150 °C

4.1: BuLi / diethyl ether / 2 h / -78 °C

4.2: diethyl ether / 20 °C

4.3: aq. HCl / 1 h / Heating

With sodium hydroxide; n-butyllithium; PPA; sodium hydride; In diethyl ether; ethanol; toluene;
DOI:10.1021/jm020895l