N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

Base Information

Chemical Name:N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide
CAS No.:1384461-94-2
Molecular Formula:C₃₉H₃₄F₂N₂O₄S
Molecular Weight:664.773
Hs Code.:

Synonyms:N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

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Chemical Property of N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

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Technology Process of N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

There total 5 articles about N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384461-93-1
((2S,3R,4S)-4-amino-4-(2,4-difluorophenyl)-2-((trityloxy)methyl)tetrahydrofuran-3-yl)methanol

: 532-55-8
Benzoyl isothiocyanate

: 1384461-94-2
N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

Guidance literature:: In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 38361-37-4
1-chloro-2,6-difluorobenzene

: 1384461-94-2
N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -75 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: zinc; acetic acid / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ammonium formate; acetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane;

Reference yield:

: 1174321-93-7
(3aR,4S)-4-((trityloxy)methyl)-3,3a,4,6-tetrahydrofuro[3,4-c]isoxazole

: 1384461-94-2
N-(((3S,4R,5S)-3-(2,4-Difluorophenyl)-4 (hydroxymethyl)-5-((trityloxy)methyl)tetrahydrofuran-3-yl)carbamothioyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -75 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: zinc; acetic acid / 20 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ammonium formate; acetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane;