(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

Base Information

Chemical Name:(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride
CAS No.:1269408-46-9
Molecular Formula:C₁₆H₁₉N₅O₃*ClH
Molecular Weight:365.819
Hs Code.:

Synonyms:(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

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Chemical Property of (2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

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Technology Process of (2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

There total 4 articles about (2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1269407-23-9
1,1-dimethylethyl ((1S)-2-{[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]amino}-1-cyclopropyl-2-oxoethyl)carbamate

: 1269408-46-9
(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 1269408-46-9
(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 2 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 1269406-69-0
1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate

: 1269408-46-9
(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-2-cyclopropylethanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;