p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Base Information

Chemical Name:p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate
CAS No.:77597-22-9
Molecular Formula:C₂₁H₂₈N₂O₆S₂Si
Molecular Weight:496.681
Hs Code.:

Synonyms:p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

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Chemical Property of p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

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Technology Process of p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

There total 1 articles about p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 77597-20-7
p-nitrobenzyl 2-<4-<<<<2-(tert-butyldimethylsilyloxy)ethyl>thio>thiocarbonyl>thio>-2-oxo-1-azetidinyl>-2-(triphenylphosphoranylidene)acetate

: 77597-22-9
p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Guidance literature:: With hydroquinone; In xylene; at 130 - 135 ℃; for 13h;

Reference yield: 94.5%

: 77597-22-9
p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

: 75527-01-4
p-nitrobenzyl 3-<(2-hydroxyethyl)thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetic acid; for 2.5h; Ambient temperature;

Reference yield:

: 77597-22-9
p-nitrobenzyl 3-<<2-(tert-butyldimethylsilyloxy)ethyl>thio>-7-oxo-4-thia-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate

: 2-(2-azidoethylthio)-3-p-nitrobenzyloxycarbonyl-7-oxo-4,7-dihydro-1,4-thiazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 94.5 percent / tetrabutylammonium fluoride / tetrahydrofuran; acetic acid / 2.5 h / Ambient temperature

2: 68 percent / Et₃N / CH₂Cl₂ / 1 h / ice-cooling

3: 44 percent / sodium azide / dimethylsulfoxide / 2 h / Ambient temperature

With sodium azide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; acetic acid; dimethyl sulfoxide;