methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

Base Information

Chemical Name:methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate
CAS No.:1147103-60-3
Molecular Formula:C₂₁H₃₁F₃N₄O₃
Molecular Weight:444.497
Hs Code.:

Synonyms:methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

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Chemical Property of methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

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Technology Process of methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

There total 2 articles about methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-nitropropan-2-ylamino)-3,3-dimethylbutanoate

: 1147103-60-3
methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 1147103-39-6
methyl (2S)-2-((2SR,3RS)-3-amino-3-cyclohexyl-1,1,1-trifluoropropan-2-ylamino)-3,3-dimethylbutanoate

: 1147103-60-3
methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

: 1147103-59-0
methyl (2S)-2-((2R,3S)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; In dichloromethane; at 20 ℃; for 72h; Product distribution / selectivity;

Reference yield:

: 1147103-60-3
methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate

: 1147103-63-6
(2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoic acid

Guidance literature:: methyl (2S)-2-((2S,3R)-3-cyclohexyl-1,1,1-trifluoro-3-(pyrazine-2-carboxamido)propan-2-ylamino)-3,3-dimethylbutanoate; With potassium trimethylsilonate; In tetrahydrofuran; at 140 ℃; for 0.166667h; Microwave irradiation;

With hydrogenchloride; water; In tetrahydrofuran; ethyl acetate;