3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester
• CAS No.: 341497-56-1
• Molecular Formula: C₁₁H₁₁ClO₃S
• Molecular Weight: 258.726
• Mol file: 341497-56-1.mol

Synonyms:3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester

Chemical Property of 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester

There total 1 articles about 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Methyl 3-mercaptopropionate (2935-90-2) + 3-Chloro-4-fluorobenzaldehyde (34328-61-5) → 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester (341497-56-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1021/jm000503f

Reference yield: 98.0%

malonic acid (141-82-2) + 3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester (341497-56-1) → (E)-3-[3-Chloro-4-(2-methoxycarbonyl-ethylsulfanyl)-phenyl]-acrylic acid

Guidance literature:

With piperidine; pyridine; at 110 ℃; for 2h;

DOI:10.1021/jm000503f

Reference yield:

3-(2-chloro-4-formyl-phenylsulfanyl)-propionic acid methyl ester (341497-56-1) → (2-chloro-4,5-diaminophenyl)[2-chloro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide (280750-10-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / piperidine; pyridine / 2 h / 110 °C

2: (COCl)2; DMF / CH₂Cl₂ / 1.5 h

3: Et₃N; DMAP / CH₂Cl₂ / 0.5 h

4: t-BuOK / tetrahydrofuran / 1 h / 20 °C

5: 93 percent / K₂CO₃ / dimethylformamide / 3 h / 70 °C

6: 44 percent / SnCl₂ / ethanol / 2 h / Heating

With piperidine; pyridine; dmap; oxalyl dichloride; potassium tert-butylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm000503f

upstream raw materials:

Methyl 3-mercaptopropionate

3-Chloro-4-fluorobenzaldehyde

Downstream raw materials:

3-[4-[3-(4-acetyl-piperazin-1-yl)-3-oxo-propenyl]-2-chlorophenylsulfanyl]-propionic acid methyl ester

(1-methylindol-5-yl)[2-chloro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide

(5-indolyl)[2-chloro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide

(benzodioxan-6-yl)[2-chloro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide