(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

Base Information

Chemical Name:(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone
CAS No.:190730-56-4
Molecular Formula:C₁₅H₁₅BrClNO₄
Molecular Weight:388.645
Hs Code.:

Synonyms:(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

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Chemical Property of (+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

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Technology Process of (+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

There total 1 articles about (+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14925-39-4
2-bromoacrolein

: 135793-05-4,113122-37-5
(4R,5S)-3-(2-chloroacetyl)-4-methyl-5-phenyloxazolidin-2-one

: 190730-56-4
(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; Yield given. Multistep reaction;
DOI:10.1016/S0040-4020(97)00412-2

Reference yield: 80.0%

: 190730-56-4
(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

: 190730-57-5
(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

Guidance literature:: With ammonium chloride; zinc; In methanol; for 6h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00412-2

Reference yield:

: 190730-56-4
(+)-4(R)-methyl-5(S)-phenyl-3-(4-bromo-2(R)-chloro-3(R)-hydroxy-4-pentenoyl)-2-oxazolidinone

: 190730-58-6
(4R,5S)-3-[(R)-4-Bromo-3-(tert-butyl-dimethyl-silanyloxy)-pent-4-enoyl]-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Zn, NH₄Cl / methanol / 6 h / Ambient temperature

2: 97 percent / 2,6=lutidine / CH₂Cl₂ / 4 h / Ambient temperature

With 2,6-dimethylpyridine; ammonium chloride; zinc; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(97)00412-2