methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

Base Information

Chemical Name:methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate
CAS No.:1189570-09-9
Molecular Formula:C₁₄H₁₅F₂NO₄
Molecular Weight:299.274
Hs Code.:

Synonyms:methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

Suppliers and Price of methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

There total 2 articles about methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220607-75-0
2-bromo-1-(3,5-difluorophenyl)ethanone

: 1187933-47-6
methyl (R)-morpholine-3-carboxylate

: 1189570-09-9
methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 869681-70-9
(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

: 1189570-09-9
methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 16 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1189570-09-9
methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate

: 107-11-9,30551-89-4
1-amino-2-propene

: 1189570-10-2
(9aR)-8-allyl-7(S)-(3,5-difluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one

: 1189570-08-8
(9aR)-8-allyl-7(R)-(3,5-difluorophenyl)hexahydropyrazino[2,1-c][1,4]oxazin-9(6H)-one

Guidance literature:: methyl 4-[2-(3,5-difluorophenyl)-2-oxoethyl]morpholine-3(R)-carboxylate; 1-amino-2-propene; In methanol; acetic acid; for 0.5h;

With sodium cyanoborohydride; In methanol; acetic acid; at 45 ℃; for 48h;