glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

Base Information

Chemical Name:glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide
CAS No.:1028745-77-8
Molecular Formula:C₄₀H₆₂Cl₂N₉O₁₃P
Molecular Weight:978.865
Hs Code.:

Synonyms:glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

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Chemical Property of glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

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Technology Process of glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

There total 8 articles about glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1028745-57-4
4-L-glutaminylamino benzyl phosphoramide mustard

: 1028746-03-3
Fm-glutaryl-Hyp-Ala-Ser-Chg-OH

: 1028745-77-8
glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

Guidance literature:: Fm-glutaryl-Hyp-Ala-Ser-Chg-OH; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h;

4-L-glutaminylamino benzyl phosphoramide mustard; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 2h;

With methanol; sodium carbonate; diethylamine; more than 3 stages;

Reference yield:

: 2419-34-3
N^α-trifluoroacetyl glutamine

: 1028745-77-8
glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-methylcyclohexylamine; triethylamine / tetrahydrofuran; toluene / 0.5 h / -15 - -10 °C

2.1: AlH₂LiSe / tetrahydrofuran / 0.58 h / 5 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / water; acetonitrile / 48 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

4.2: 2 h / 20 °C

5.1: diethylamine / acetonitrile; methanol / 1 h

With N-methylcyclohexylamine; AlH₂LiSe; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; toluene; acetonitrile;
DOI:10.1016/j.bmc.2016.04.035

Reference yield:

: 1028745-36-9
4-(Nα-trifluoroacetyl-L-glutaminyl)amidobenzylphosphoramide

: 1028745-77-8
glutaryl-Hyp-Ala-Ser-Chg-Gln-NH-benzyl phosphoramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / water; acetonitrile / 48 h / 20 °C

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: diethylamine / acetonitrile; methanol / 1 h

With potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol; water; acetonitrile;
DOI:10.1016/j.bmc.2016.04.035