Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

Base Information

Chemical Name:Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate
CAS No.:1390640-92-2
Molecular Formula:C₁₃H₉ClFIN₂O₂
Molecular Weight:406.583
Hs Code.:

Synonyms:Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

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Chemical Property of Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

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Technology Process of Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

There total 7 articles about Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1390640-88-6
methyl 4-amino-6-(4-chlorophenyl)-5-fluoropicolinate

: 1390640-92-2
Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

Guidance literature:: With iodine; periodic acid; In methanol; for 16h; Reflux;

Reference yield:

: 496849-98-0
4,5,6-trichloro-2-pyridinecarbonitrile

: 1390640-92-2
Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

Guidance literature:: Multi-step reaction with 6 steps

1: cesium fluoride / dimethyl sulfoxide / 24 h / 75 - 110 °C / Inert atmosphere

2: triphenylphosphine; dipotassium hydrogenphosphate / bis(benzonitrile)palladium(II) dichloride / acetonitrile; water / 5 h / Inert atmosphere; Reflux

3: cesium fluoride / dimethyl sulfoxide / 4 h / 105 °C / Inert atmosphere

4: ammonia / dimethyl sulfoxide / 48 h

5: sulfuric acid / methanol / 168 h / 110 °C / sealed tube

6: iodine; periodic acid / methanol / 16 h / Reflux

With dipotassium hydrogenphosphate; sulfuric acid; ammonia; iodine; periodic acid; triphenylphosphine; cesium fluoride; bis(benzonitrile)palladium(II) dichloride; In methanol; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1391055-83-6
4,5,6-trifluoropicolinonitrile

: 1390640-92-2
Methyl 4-amino-6-(4-chlorophenyl)-5-fluoro-3-iodopicolinate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; dipotassium hydrogenphosphate / bis(benzonitrile)palladium(II) dichloride / acetonitrile; water / 5 h / Inert atmosphere; Reflux

2: cesium fluoride / dimethyl sulfoxide / 4 h / 105 °C / Inert atmosphere

3: ammonia / dimethyl sulfoxide / 48 h

4: sulfuric acid / methanol / 168 h / 110 °C / sealed tube

5: iodine; periodic acid / methanol / 16 h / Reflux

With dipotassium hydrogenphosphate; sulfuric acid; ammonia; iodine; periodic acid; triphenylphosphine; cesium fluoride; bis(benzonitrile)palladium(II) dichloride; In methanol; water; dimethyl sulfoxide; acetonitrile;