methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate

Base Information

• Chemical Name: methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate
• CAS No.: 67201-23-4
• Molecular Formula: C₁₄H₂₈O₃Si₂
• Molecular Weight: 300.546
• Mol file: 67201-23-4.mol

Synonyms:methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate

Chemical Property of methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate

There total 6 articles about methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(E)-1-trimethylsilyl-3-trimethylsilyloxybuta-1,3-diene (80400-53-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate (67201-23-4)

Guidance literature:

With hydroquinone; at 120 ℃; for 40h;

DOI:10.1039/P19810002415

Reference yield:

(E)-1-trimethylsilyl-1-buten-3-one (49750-09-6) → methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate (67201-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / BuLi, di-isopropylamine / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

2: 63 percent / hydroquinone / 40 h / 120 °C

With n-butyllithium; diisopropylamine; hydroquinone; In tetrahydrofuran; hexane;

DOI:10.1039/P19810002415

Reference yield:

(E)-4-(trimethylsilyl)but-3-en-2-ol (56919-90-5) → methyl 2-trimethylsilyl-4-trimethylsilyloxycyclohex-3-enecarboxylate (67201-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / manganese dioxide / light petroleum / 12 h / Ambient temperature

2: 84 percent / BuLi, di-isopropylamine / tetrahydrofuran; hexane / 4 h / -78 - 20 °C

3: 63 percent / hydroquinone / 40 h / 120 °C

With manganese(IV) oxide; n-butyllithium; diisopropylamine; hydroquinone; In tetrahydrofuran; hexane; Petroleum ether;

DOI:10.1039/P19810002415

upstream raw materials:

(E)-1-trimethylsilyl-3-trimethylsilyloxybuta-1,3-diene

acrylic acid methyl ester

(E)-1-trimethylsilyl-1-buten-3-one

(E)-4-(trimethylsilyl)but-3-en-2-ol

Downstream raw materials:

methyl 3-bromo-4-hydroxybenzoate

methyl 4-oxocyclohex-1-ene-1-carboxylate

methyl 4-oxocyclohex-2-ene-1-carboxylate

4-Oxo-2-(trimethylsilyl)cyclohexancarbonsaeure-Methylester