1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

Base Information

Chemical Name:1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea
CAS No.:1341124-12-6
Molecular Formula:C₂₁H₂₁F₃N₄O₂
Molecular Weight:418.419
Hs Code.:

Synonyms:1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

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Chemical Property of 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

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Technology Process of 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

There total 8 articles about 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54523-76-1
4-aminoindolin-2-one

: 1338065-38-5
C₁₃H₁₃F₃N₂O

: 1341124-12-6
1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

Guidance literature:: In N,N-dimethyl-formamide; at 0 - 80 ℃; for 4h;

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 1341124-12-6
1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 100 °C

1.2: 3 h / 100 °C

2.1: toluene-4-sulfonic acid / acetic acid / 3 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 0 - 80 °C / 3102.97 Torr

4.1: toluene-4-sulfonic acid / N,N-dimethyl-formamide; ethanol / 2 h / Reflux

5.1: N,N-dimethyl-formamide / 4 h / 0 - 80 °C

With hydrogen; sodium hydride; toluene-4-sulfonic acid; palladium 10% on activated carbon; In ethanol; acetic acid; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 86162-89-2
dimethyl (2,6-dinitrophenyl)malonate

: 1341124-12-6
1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / acetic acid / 3 h / Reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 0 - 80 °C / 3102.97 Torr

3: toluene-4-sulfonic acid / N,N-dimethyl-formamide; ethanol / 2 h / Reflux

4: N,N-dimethyl-formamide / 4 h / 0 - 80 °C

With hydrogen; toluene-4-sulfonic acid; palladium 10% on activated carbon; In ethanol; acetic acid; N,N-dimethyl-formamide;