ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

Base Information

Chemical Name:ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate
CAS No.:920509-94-0
Molecular Formula:C₂₁H₂₂Cl₂N₆O₄
Molecular Weight:493.349
Hs Code.:

Synonyms:ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

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Chemical Property of ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

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Technology Process of ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

There total 8 articles about ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 920509-93-9
6-(4-amino-2,6-dichlorobenzyl)-4-isopropyl-2-methyl-2H-pyridazin-3-one

: 68168-42-3
N-cyanoacetylurethane

: 920509-94-0
ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

Guidance literature:: 6-(4-amino-2,6-dichlorobenzyl)-4-isopropyl-2-methyl-2H-pyridazin-3-one; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.75h; Inert atmosphere;

N-cyanoacetylurethane; With pyridine; In water; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm4019299

Reference yield:

: 920509-92-8
2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)isoindoline-1,3-dione

: 920509-94-0
ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 3 h / 110 °C / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With hydrogenchloride; acetic acid; sodium nitrite; In water;
DOI:10.1021/jm4019299

Reference yield:

: 920509-91-7
2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)isoindoline-1,3-dione

: 920509-94-0
ethyl (2-cyano-2-(2-(3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl)phenyl)hydrazono)acetyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4.5 h / 105 °C / Inert atmosphere

2.1: acetic acid / 3 h / 110 °C / Inert atmosphere

3.1: hydrogenchloride; sodium nitrite / water / 0.75 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C / Inert atmosphere

With hydrogenchloride; acetic acid; sodium nitrite; In water;
DOI:10.1021/jm4019299