2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

Base Information

Chemical Name:2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide
CAS No.:1590397-41-3
Molecular Formula:C₂₄H₂₃F₄N₃O₃S
Molecular Weight:509.525
Hs Code.:

Synonyms:2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

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Chemical Property of 2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

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Technology Process of 2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

There total 4 articles about 2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1184104-67-3
[(3-fluorobenzenesulfonyl)(isopropyl)amino]acetic acid

: 1503922-74-4
C-[2-(4-trifluoromethylphenyl)pyridin-4-yl]-methylamine

: 1590397-41-3
2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 10386-27-3
2-bromoisonicotinonitrile

: 1590397-41-3
2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 14 h / 120 °C / Inert atmosphere; Sealed tube

2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C / 2585.81 Torr

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 25 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

Reference yield:

: 1257437-26-5
2-[4-(trifluoromethyl)phenyl]pyridine-4-carbonitrile

: 1590397-41-3
2-[(3-fluorobenzenesulfonyl)(isopropyl)amino]-N-[2-(4-trifluoromethylphenyl)-pyridin-4-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 25 °C / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h / 25 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane;