4-Chloro-2-oxo-1-phenylquinoline-3-carbaldehyde

Base Information

Chemical Name:4-Chloro-2-oxo-1-phenylquinoline-3-carbaldehyde
CAS No.:148587-01-3
Molecular Formula:C₁₆H₁₀ClNO₂
Molecular Weight:283.714
Hs Code.:
DSSTox Substance ID:DTXSID10382728
Wikidata:Q82174121

Synonyms:ST50996721;DTXSID10382728;AKOS024364469;148587-01-3

Suppliers and Price of 4-Chloro-2-oxo-1-phenylquinoline-3-carbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-2-oxo-1-phenylquinoline-3-carbaldehyde

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:283.0400063
Heavy Atom Count:20
Complexity:440

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)N2C3=CC=CC=C3C(=C(C2=O)C=O)Cl

Technology Process of 4-Chloro-2-oxo-1-phenylquinoline-3-carbaldehyde

There total 4 articles about 4-Chloro-2-oxo-1-phenylquinoline-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 148586-99-6
4-chloro-3-dichloromethyl-1-phenyl-quinolin-2(1H)-one

: 148587-01-3
4-Chloro-2-oxo-1-phenyl-1,2-dihydro-quinoline-3-carbaldehyde

Guidance literature:: With sulfuric acid; at 70 ℃; for 2h;
DOI:10.1002/prac.19933350203

Reference yield: 65.0%

: 59856-29-0
1-Phenyl-3-[1-phenylamino-meth-(Z)-ylidene]-1H-quinoline-2,4-dione

: 148587-01-3
4-Chloro-2-oxo-1-phenyl-1,2-dihydro-quinoline-3-carbaldehyde

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1002/prac.19933350203

Reference yield:

: 14994-75-3
4-hydroxy-1-phenylquinolin-2(1H)-one

: 148587-01-3
4-Chloro-2-oxo-1-phenyl-1,2-dihydro-quinoline-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / ethane-1,2-diol / 190 °C

2: 81 percent / 2 N aq. NaOH / dioxane / 2 h / 100 °C

3: 95 percent / POCl₃ / 16 h / Heating

4: 84 percent / H₂SO₄ / 2 h / 70 °C

With sodium hydroxide; sulfuric acid; trichlorophosphate; In 1,4-dioxane; ethylene glycol;
DOI:10.1002/prac.19933350203