2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE

Base Information

• Chemical Name: 2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE
• CAS No.: 120319-05-3
• Molecular Formula: C13H15 N3 O
• Molecular Weight: 229.2777
• Hs Code.: 2934999090
• Mol file: 120319-05-3.mol

Synonyms:2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE

Chemical Property of 2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE

Chemical Property:

• Refractive Index: 1.593
• PSA: 46.92000
• Density: 1.14g/cm³
• LogP: 2.23960

Purity/Quality:

99%min ^*data from raw suppliers

2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE

There total 2 articles about 2,5-DIMETHYL-4-METHYLCARBAMOYL-1-PHENYLIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-Acetamido-3,6-dimethyl-1-phenyluracil (120319-00-8) → N',2,5-Trimethyl-1-phenyl-1H-imidazole-4-carboxamide (120319-05-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1016/S0040-4039(00)80560-2

Reference yield:

5-amino-3,6-dimethyl-1-phenyluracil (32150-36-0) → N',2,5-Trimethyl-1-phenyl-1H-imidazole-4-carboxamide (120319-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 3 h / Ambient temperature

2: 81 percent / 5percent aq.NaOH / ethanol / 3 h / Heating

With sodium hydroxide; In ethanol;

upstream raw materials:

5-Acetamido-3,6-dimethyl-1-phenyluracil

5-amino-3,6-dimethyl-1-phenyluracil

Refernces

• 1、 Ueda,Matsuura,Murakami,Nagai,Sakakibara,Goto. "A novel ring transformation of 5-acylaminouracils and 5-acylaminopyrimidin-4(3H)-ones into imidazoles". . p. 4607 - 4610. Retrieved 2007/10/02.