⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

Base Information

Chemical Name:⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride
CAS No.:1346017-91-1
Molecular Formula:C₁₅H₁₈ClF₃N₂O₂
Molecular Weight:350.768
Hs Code.:

<sup>(3)</sup>-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

Synonyms:⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

Chemical Property:

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Technology Process of ⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

There total 5 articles about ⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1312072-46-0
3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl) propionic acid

: 1346017-91-1
⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

Guidance literature:: With thionyl chloride; for 3h; Reflux;

Reference yield:

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1346017-91-1
⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide / tetrahydrofuran / 1 h / 20 °C

2: trifluoroacetic acid; water / 0.5 h / 20 °C

3: potassium carbonate / acetonitrile / 3 h / Reflux

4: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

5: thionyl chloride / 3 h / Reflux

With thionyl chloride; water; potassium carbonate; trifluoroacetic acid; sodium iodide; sodium hydroxide; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1373886-26-0
ethyl 3-(4-((4-trifluoromethoxy)benzyl)piperazin-1-yl)propionate

: 1346017-91-1
⁽³⁾-3-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)propionyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / tetrahydrofuran / 0 - 20 °C

2: thionyl chloride / 3 h / Reflux

With thionyl chloride; water; sodium hydroxide; In tetrahydrofuran;