1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

Base Information

Chemical Name:1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one
CAS No.:221382-10-1
Molecular Formula:C₃₁H₃₂N₄O₉
Molecular Weight:604.616
Hs Code.:

Synonyms:1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

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Chemical Property of 1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

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Technology Process of 1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

There total 7 articles about 1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 25508-20-7
N,N'-dibenzyloxycarbonyl-(S)-methyl-isothiourea

: 221382-09-8
1-(4-methoxycarbonyl-2-aminophenyl)-5,5-bis(hydroxymethyl)pyrrolidin-2-one

: 221382-10-1
1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; a) 0 deg C, 3 h, b) RT, 12 h;
DOI:10.1021/jm980707k

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 221382-10-1
1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / 16 h / 115 °C

2: 89 percent / PCl₃ / benzene / 30 h / Heating

3: 98 percent / NaH / dimethylformamide / 2 h / Ambient temperature

4: 95 percent / NO₂BF₄ / CH₂Cl₂ / 3 h / 5 - 10 °C

5: 62 percent / NaBH₄ / tetrahydrofuran; methanol / 14 h / 0 °C

6: 87 percent / H₂ / 10 percent Pd/C / methanol / 1 h / 2585.74 Torr

7: 71 percent / Et₃N, HgCl₂ / dimethylformamide / a) 0 deg C, 3 h, b) RT, 12 h

With sodium tetrahydroborate; nitronium tetrafluoborate; hydrogen; sodium hydride; triethylamine; mercury dichloride; phosphorus trichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm980707k

Reference yield:

: 221382-03-2
diethyl 2-[4-(methoxycarbonyl)phenylamino]malonate

: 221382-10-1
1-<4-methoxycarbonyl-2-(N,N'-bis(benzyloxycarbonyl)guanidino)phenyl>-5,5-bis(hydroxymethyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / PCl₃ / benzene / 30 h / Heating

2: 98 percent / NaH / dimethylformamide / 2 h / Ambient temperature

3: 95 percent / NO₂BF₄ / CH₂Cl₂ / 3 h / 5 - 10 °C

4: 62 percent / NaBH₄ / tetrahydrofuran; methanol / 14 h / 0 °C

5: 87 percent / H₂ / 10 percent Pd/C / methanol / 1 h / 2585.74 Torr

6: 71 percent / Et₃N, HgCl₂ / dimethylformamide / a) 0 deg C, 3 h, b) RT, 12 h

With sodium tetrahydroborate; nitronium tetrafluoborate; hydrogen; sodium hydride; triethylamine; mercury dichloride; phosphorus trichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm980707k