2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride

Base Information

• Chemical Name: 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride
• CAS No.: 84772-28-1
• Molecular Formula: C₁₂H₁₃N₃O*ClH
• Molecular Weight: 251.716
• Mol file: 84772-28-1.mol

Synonyms:2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride

Chemical Property of 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride

There total 1 articles about 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

isatoic anhydride (118-48-9) + ornithine ethyl ester dihydrochloride (84772-29-2,94231-37-5) → 3-3'-(2''-aminobenzoyl)aminopropyl-1,4-benzodiazepine-2,5-dione (88369-27-1) + 2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride (84772-28-1)

Guidance literature:

In pyridine; for 8h; Product distribution; Heating; various solvents, various temperatures, various time;

DOI:10.1002/jhet.5570200535

Reference yield: 100.0%

2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride (84772-28-1) → 5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one (885-70-1)

Guidance literature:

palladium on activated charcoal; In pyridine; for 24h; Heating;

DOI:10.1002/jhet.5570200535

Reference yield:

2,3,4,4a,5,11-hexahydro-6H-pyrido<2,3-b><1,4>benzodiazepin-6-one hydrochloride (84772-28-1) → 3-(2'-aminobenzoyl)aminopiperidin-2-one (84772-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / H₂O / 36 h / Ambient temperature

2: 79 percent / 25percent aq. NaOH / H₂O / 2 h / Ambient temperature

3: 100 percent / melting

With sodium hydroxide; water; In water;

DOI:10.1002/jhet.5570200535

upstream raw materials:

isatoic anhydride

ornithine ethyl ester dihydrochloride

Downstream raw materials:

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

3-(2'-aminobenzoyl)aminopiperidin-2-one