cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester

Base Information

• Chemical Name: cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester
• CAS No.: 522612-52-8
• Molecular Formula: C₂₂H₁₉FN₂O₃
• Molecular Weight: 378.403
• Mol file: 522612-52-8.mol

Synonyms:cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester

Chemical Property of cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester

There total 3 articles about cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

isopropyl cyanoacetate (13361-30-3) + 5-fluoro-1-(4-methylbenzyl)isatin (85511-64-4) → cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester (522612-52-8)

Guidance literature:

With piperidine; In isopropyl alcohol; for 0.25h; Heating;

DOI:10.1021/jm030762f

Reference yield:

5-fluoro-1H-indole-2,3-dione (443-69-6) → cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester (522612-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: 54 percent / dimethylformamide / 20 °C

2.1: 60 percent / piperidine / propan-2-ol / 0.25 h / Heating

With piperidine; sodium hydride; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm030762f

Reference yield:

4-Methylbenzyl bromide (104-81-4) → cyano<5-fluoro-1-(4-methylbenzyl)-2-oxo-2,3-dihydroindol-3-ylidene>acetic acid isopropyl ester (522612-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: 54 percent / dimethylformamide / 20 °C

2.1: 60 percent / piperidine / propan-2-ol / 0.25 h / Heating

With piperidine; sodium hydride; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm030762f

upstream raw materials:

isopropyl cyanoacetate

5-fluoro-1-(4-methylbenzyl)isatin

5-fluoro-1H-indole-2,3-dione

4-Methylbenzyl bromide