[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

Base Information

Chemical Name:[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester
CAS No.:1173056-12-6
Molecular Formula:C₅₇H₉₅N₅O₉
Molecular Weight:994.409
Hs Code.:

[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

Synonyms:[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

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Chemical Property of [4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

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Technology Process of [4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

There total 6 articles about [4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1016237-83-4
tert-butyl {4-[3-(4-amino-phenyl)-2-(tert-butoxycarbonylmethyl-amino)-propyl]-7-tert-butoxycarbonylmethyl-[1,4,7]triazonan-1-yl}-acetate

: 1173056-04-6
(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-1-(2-thioxothiazolidin-3-yl)pentan-1-one

: 1173056-12-6
[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 48h; Reflux;
DOI:10.1039/b823000e

Reference yield:

: tert-butyl {4-tert-butoxycarbonylmethyl-7-[2-(tert-butoxycarbonylmethyl-amino)-3-(4-nitro-phenyl)-propyl]-[1,4,7]-triazonan-1-yl}-acetate

: 1173056-12-6
[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 14 h / 20 °C / 1034.32 Torr

2: triethylamine / dichloromethane / 48 h / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;

Reference yield:

: 474-25-9
chenodeoxycholic acid

: 1173056-12-6
[4-tert-butoxycarbonylmethyl-7-(2-(tert-butoxycarbonyl methyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]-phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h

2: triethylamine / dichloromethane / 48 h / Reflux

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;