1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

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Chemical Name:1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione
CAS No.:853058-46-5
Molecular Formula:C₁₉H₁₆ClN₅O₃
Molecular Weight:397.821
Hs Code.:

Synonyms:1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

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Chemical Property of 1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

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Technology Process of 1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

There total 7 articles about 1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 474010-69-0
N-benzoyl-N'-cyanomethylpiperazine

: 853058-44-3
4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carbonyl chloride

: 853058-46-5
1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

Guidance literature:: N-benzoyl-N'-cyanomethylpiperazine; 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carbonyl chloride; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 2h;

With peracetic acid; In tetrahydrofuran; acetic acid; toluene; at 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water; acetic acid; toluene;

Reference yield:

: C₂₀H₁₇ClN₆O₂

: 853058-46-5
1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

Guidance literature:: With peracetic acid; potassium hexamethylsilazane; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2012.10.118

Reference yield:

: 853058-40-9
diethyl 3-amino-1H-2,4-pyrroledicarboxylate

: 853058-46-5
1-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-ethane-1,2-dione

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / Reflux

2: lithium hydroxide; water / tetrahydrofuran / 90 °C

3: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide

4: potassium hexamethylsilazane / tetrahydrofuran / -78 °C

5: potassium hexamethylsilazane; peracetic acid / tetrahydrofuran / -78 - 20 °C

With peracetic acid; oxalyl dichloride; water; potassium hexamethylsilazane; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.10.118